ceesdekker.net - An Overview
ceesdekker.net - An Overview
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Spatial construction facilitates cooperation within a social Predicament: empirical proof from the bacterial Local community
Our team reports bacterial mobile division and is particularly aiming to represent a ‘bottom up biology’ in synthetic cells which can autonomously divide. Our principal fascination lies in cell division, chromatin composition, and spatial Regulate.
Back in 1991, Sumio Iijima of your NEC Company experienced claimed the synthesis of carbon nanotubes. Band composition calculations instructed that these nanotubes could show metallic band conduction. This may be a significant benefit about the conducting polymers we experienced explored, which were, in reality, disordered semiconductors giving just variable-selection hopping conductivity.
2007, to start with actual-time detection of strand Trade in homologous recombination by RecA; discovery of a minimal persistence duration of ends of microtubules; and settled the system of biosensing with carbon nanotubes
2015, discovery that condensin is actually a extremely adaptable protein framework; and very first detection of DNA knots using nanopores
The coiled-coil on the human Rad50 DNA restore protein incorporates distinct segments of elevated adaptability
Because 2000 he moved to solitary-molecule biophysics and nanobiology, with investigation from DNA supercoiling reports of nucleosomes and DNA fix proteins to DNA translocation by means of nanopores. Not too long ago his study has focused on finding out cell division with bacteria on chip, when his supreme interest is during the course of recognizing artificial cells.
Atomic drive microscopy exhibits that vaccinia topoisomerase IB generates filaments on DNA in the cooperative manner
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Presently, we also recognized that it ought to be achievable to utilize just one semiconducting carbon nanotube to create a transistor — and we set out to really make it. We stretched unique semiconducting nanotubes throughout metallic electrodes and utilised the underlying silicon substrate as ceesdekker being a gate electrode, establishing The essential 3-terminal format of a industry-outcome transistor (Fig.
Illustration (4) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in grey, the rim in the pore is highlighted in purple, along with a 3D rendering on the movement with the DNA rod is displayed.
Later on we spoke all over again briefly simply because Dekker felt that our discussion of his religion immediately turned purely philosophical, Whilst Additionally, it concretely helps him in his get the job done.
Visualization of unstained DNA nanostructures with Innovative in-emphasis transmission electron microscopy approaches
Reliable-condition nanopores have tested to generally be a shockingly versatile probe for solitary-molecule Examination of DNA. I will describe some of our current findings – specifically DNA knots – as well as our endeavours to extend the abilities of stable-condition nanopores even even more, inside the path of single-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.